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Don’t Be Fooled By Glucose

by Domingo Krajewski (2025-05-04)

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First, we should try to see how much mileage we can get out of predicting future blood glucose levels with past glucose levels. Short-term blurriness due to high or low blood sugar levels will usually resolve when blood sugar levels return to 70-130 milligrams per deciliter (mg/dL). Next, the carb intakes will be similar to the insulin intake but trickier, since there is more than one type of carb and different types get absorbed at different rates, but are all absorbed by the bloodstream in a vaguely similar way, which is to say like a bell curve. The most obvious candidates are the insulin intakes and the carb intakes. We will have to be pretty careful to add the carb intake model, since probably the overall model will depend dramatically on our choices. Actually the weird values at the beginning are easy to take care of- since we are going to work causally, we will know there had been a gap and the data just restarted, so we we will know to ignore the values for a while (we will determine how long shortly) until we can trust the numbers. Heavily processed and junk foods often contain added sugar, a fast-acting carbohydrate that can quickly spike insulin levels.



However, this calibration becomes more difficult immediately after the patient eats or drinks something sugary, because blood glucose soars rapidly, while it takes five to 10 minutes to see a corresponding surge in the interstitial fluid glucose levels. Some simple moves to incorporate more activity in your life is to stretch for 10 minutes after you wake up in the morning, walk to your workplace if it is around the corner, take the stairs whenever possible, and sit on an exercise ball while watching TV. Unfortunately he didn’t do this every five minutes (well actually that’s a good thing for him), and in particular during the night there were long gaps of time when we don’t have any manual measurements. We also need to guess at the standard deviation, although we have a pretty good head start knowing the 1.5 hours clue. It remains to guess what the maximum height should be, but it very likely depends linearly on the amount of insulin that was taken. I would venture to guess that this food has much more fat, calories, and sodium than you would find in your own kitchen. Moreover, we see crazy values more often near the gaps. Looking back at the data, we see gaps and we see crazy values sometimes.



But let’s get back to the first step of modeling, which is just using past log glucose levels to predict the next glucose level (we will later try to expand supports natural energy the horizon of the model to predict glucose levels an hour from now). But if results come back abnormal, that may mean you have to redo the bloodwork while fasting. In general it’s a good idea to use at most two thirds of your data as in-sample; otherwise your out-of-sample test is not sufficiently meaningful (assuming you don’t have that much data, which always seems to be the case). One good stare at the data will tell us there’s probably more than one past data point that will be needed, since we see that there is pretty consistent moves upwards and downwards. Keeping in mind that the previous post had us using log levels instead of actual glucose levels, since then the distribution of levels is more normal, we will actually be trying to predict log glucose levels (log levels) knowing past log glucose levels. Elevated glucose levels over many years can contribute to the build-up of fatty deposits in the blood vessels called plaque. So it’s possible we can incorporate that data into the model as well, once we have some idea of how the glucose is effected by the time of day.



One of the major obstacles they have faced is that near-infrared light penetrates only about half a millimeter below the skin, so it measures the amount of glucose in the fluid that bathes skin cells (known as interstitial fluid), not the amount in the blood. To address that lag time, Barman and Kong developed a new calibration method, called Dynamic Concentration Correction (DCC), which incorporates the rate at which glucose diffuses from the blood into the interstitial fluid. To overcome this, the team came up with an algorithm that relates the two concentrations, allowing them to predict blood glucose levels from the glucose concentration in interstitial fluid. Measuring glucose levels after meals is important not just for sugar balance supplement diagnosis, but in the treatment of diabetes too. In a 2013 study, 60 people with type 2 diabetes and obesity took either metformin alone or a combination of metformin and garlic twice daily after meals for supports natural energy 12 weeks. According to one study, eating an olive oil-rich Mediterranean diet for Glyco Care Supplement 1.5 years improved arterial blood flow better than a standard low-fat diet in people with type 2 diabetes and prediabetes. One group was asked to consume 80% of their calories before 1 p.m.-a type of intermittent fasting known as early time-restricted feeding, or eTRF.



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